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Clinical correlates of transpulmonary pressure
- In the absence of airflow, transairway (resistive) pressure is zero. Hence, transpulmonary pressure equals transalveolar pressure and is thus a true marker of lung stress.
- End-inspiratory transpulmonary pressure is thus a better marker of inspiratory lung stress compared to plateau pressure.
- End-inspiratory transpulmonary pressure can be used to guide selection of optimal PEEP
- From the mechanics standpoint, the alveolus does not care whether a given transalveolar pressure is generated by PPV, NPV or a combination of the two.